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2015

原著:呼吸器グループ

  • Abe H, Kawahara A, Azuma K, Taira T, Takase Y, Fukumitsu C, Yamaguchi T, Murata K, Akiba J, Okamoto I, Hoshino T, Takamori S, Kage M. Heterogeniety of ALK gene rearrangement in non-small cell lung carcinoma: a comparative study between small biopsy and excision samples. J Thorac Oncol. 2015;10: 800-805.
  • Smith SG, Gugilla A, Mukherjee M, Merim K, Irshad A, Tang W, Kinoshita T, Watson B, Oliveria JP, Comeau M, O'Byrne PM, Gauvreau GM, Sehmi R.Thymic stromal lymphopoietin and IL-33 modulate migration of hematopoietic progenitor cells in patients with allergic asthma.J Allergy Clin Immunol. 2015;135(6):1594-1602
  • Matsumoto K, Kawayama T, Kinoshita T, Minami S, Matsunaga K, Nagafuchi M, Hoshino T, Rikimaru T. Chronic Rhinosinusitis is Associated with Airflow Obstruction in Japanese Never-Smokers without Asthma. Int J Respir Pulm Med 2015;2:023
  • Tanaka M, Ishii H, Azuma K, Saisho C, Matsuo N, Imamura Y, Tokito T, Kinoshita T, Yamada K, Takedatsu H, Mitsuyama K, Hoshino T. Ulcerative colitis in a patient with non-small-cell lung cancer receiving bevacizumab. Invest New Drugs. 2015; 33: 1133-1135.
  • Ishii H, Azuma K, Sakai K, Kawahara A, Yamada K, Tokito T, Okamoto I, Nishio K, Hoshino T. Digital PCR analysis of plasma cell-free DNA for non-invasive detection of drug resistance mechanisms in EGFR mutant NSCLC: Correlation with paired tumor samples. Oncotarget. 2015; 31: 30850-30858.
  • Okamoto I, Miyazaki M, Takeda M, Terashima M, Azuma K, Hayashi H, Kaneda H, Kurata T, Tsurutani J, Seto T, Hirai F, Konishi K, Sarashina A, Yagi N, Kaiser R, Nakagawa K. The tolerability of nintedanib (BIBF1120) in combination with docetaxel: a phase 1 study in Japanease patients with previously treated non-small-cell lung cancer. J Thorac Oncol .2015;10: 346-352.
  • Tokito T, Murakami H, Mori K, Osaka I, Takahashi T. Toxicity and efficacy of chemotherapy for non-small cell lung cancer with cavitary lesions. Implementation status and explanatory analysis of early advance care planning for stage IV non-small cell lung cancer patients. JJCO 2015;45(3):261-266.
  • Tajiri M, Okamoto M, Fujimoto K,Johkoh T, Ono J, Tominaga M, Azuma K, Kawayama T, Ohta S, Izuhara K, Hoshino T. Serum Level of Periostin Can Predict Long-term Outcome of Idiopathic Pulmonary Fibrosis.Respiratory Investigation 2015;53(2):73-81.
  • Ishii H, Azuma K, Kawahara A, Yamada K, Imamura Y, Tokito T, Kinoshita T, Kage M, Hoshino T. Significance of programmed cell death-ligand 1 expression and its association with survival in patients with small cell lung cancer. J Thorac Oncol. 2015; 10: 426-430.
  • Smith SG, Gugilla A, Mukherjee M, Merim K, Irshad A, Tang W, Kinoshita T, Watson B, Oliveria JP, Comeau M, O'Byrne PM, Gauvreau GM, Sehmi R.Thymic stromal lymphopoietin and IL-33 modulate migration of hematopoietic progenitor cells in patients with allergic asthma.J Allergy Clin Immunol. 2015;135(6):1594-1602
  • Kinoshita T, Kawayama T, Imamura Y, Sakazaki Y, Hirai R, Ishii H, Suetomo M, Matsunaga K, Azuma K, Fujimoto K, Hoshino T.Paired maximum inspiratory and expiratory plain chest radiographs for assessment of airflow limitation in chronic obstructive pulmonary disease.Eur J Radiol. 2015;84(4):726-731.
  • Yamada K, Aono H, Hosomi Y, Okamoto H, Kato T, Komase Y, Nishikawa M, Azuma K, Takeoka H, Okuma Y, Nakahara Y, Sato A, Oba MS, Morita S, Kunitoh H, Watanabe K. A prospective, multicentre phase II trial of low-dose erlotinib in non-small cell lung cancer patients with EGFR mutations pretreated with chemotherapy: Thoracic Oncology Research Group 0911. Eur J Cancer. 2015 Jul 11. [Epub ahead of print]

原著:神経グループ

  • Hauser MA, Aboobakar IF, Liu Y, Miura S, Whigham BT, Challa P, Wheeler J, Williams A, Santiago-Turla C, Qin X, Rautenbach RM, Ziskind A, Ramsay M, Uebe S, Song L, Safi A, Vithana EN, Mizoguchi T, Nakano S, Kubota T, Hayashi K, Manabe S, Kazama S, Mori Y, Miyata K, Yoshimura N, Reis A, Crawford GE, Pasutto F, Carmichael TR, Williams SE, Ozaki M, Aung T, Khor CC, Stamer WD, Ashley-Koch AE, Allingham RR. Genetic variants and cellular stressors associated with exfoliation syndrome modulate promoter activity of a lncRNA within the LOXL1 locus. Hum Mol Genet 2015; 24: 6552-63.
  • Sano K, Miura S, Fujiwara T, Fujioka R, Yorita A, Noda K, Kida H, Azuma K, Kaieda S, Yamamoto K, Taniwaki T, Fukumaki Y, Shibata H. A novel missense mutation of RYR1 in familial idiopathic hyper CK-emia. J Neurol Sci 2015; 356: 142-7.

原著:膠原病グループ

  • Yasunami M, Nakamura H, Agematsu K, Nakamura A, Yazaki M, Kishida D, Yachie A, Toma T, Masumoto J, Ida H, Koga T, Kawakami A, Eguchi K, Furukawa H, Nakamura T, Nakamura M, Migita K. Identification of disease-promoting HLA class I and protective class II modifiers in Japanese patients with Familial Mediterranean Fever. PLoS One. 2015 ;14;10(5):e0125938.
  • Horai Y, Koga T, Fujikawa K, Takatani A, Nishino A, Nakashima Y, Suzuki T, Kawashiri SY, Iwamoto N, Ichinose K, Tamai M, Nakamura H, Ida H, Kakugawa T, Sakamoto N, Ishimatsu Y, Mukae H, Hamaguchi Y, Fujimoto M, Kuwana M, Origuchi T, Kohno S, Kawakami A. Serum interferon-α is a useful biomarker in patients with anti-melanoma differentiation-associated gene 5 (MDA5) antibody-positive dermatomyositis. Mod Rheumatol. 2015 ;25(1):85-89.




2014

原著:呼吸器グループ

  • Watari K, Shibata T, Kawahara A, Sata K, Nabeshima H, Shinoda A, Abe H, Azuma K, Murakami Y, Izumi H, Takahashi T, Kage M, Kuwano M, Ono M. Tumor-Derived Interleukin-1 Promotes Lymphangiogenesis and Lymph Node Metastasis through M2-Type Macrophages. PLos One 2014; 9: e99568
  • Azuma K, Komatsu N, Hattori S, Matsueda S, Kawahara A, Sasada T, Itoh K, Hoshino T. Humoral immune responses to EGFR-derived peptides predict progression-free survival and overall survival of non-small cell lung cancer patients receiving gefitinib. PLos One 2014; 9:e86667.
  • Kawahara A, Taira T, Abe H, Watari K, Murakami Y, Fukumitsu C, Takase Y, Yamaguchi T, Azuma K, Akiba J, Ono M, Kage M. Fixation effect of surpath preservative fluids using EGFR mutation specific antibodies for immunohistochemistry. Cancer Cytopathol 2014; 122: 145-52.
  • Kinoshita T, Baatjes A, Smith SG, et al.Natural T regulatory cells in isolated early responder compared to dual responder subjects with allergic asthma. J Allergy Clin Immunol. 2014;133(3):696-703
  • Tokito T, Shukuya T, Akamatsu H, Ono A, Taira T, Kenmotsu H, Naito T, Murakami H, Takahashi T, Endo M, Mori K, Yamamoto N. Toxicity and efficacy of chemotherapy for non-small cell lung cancer with cavitary lesions. Respiratory Investigation 2014;52(3):184-9.
  • Shirai T, Kawayama T, Nagase H, Inoue H, Sato S, Asano K, Kume H. Exhaled nitric oxide measurement may predict asthma exacerbation after stepping down Formoterol/Budesonide combination therapy in adult asthma. J Allergy Ther 2014;5:3.
  • Yamada K, Takeoka H, Mizoguchi Y, Yamashita F, Yoshida T, Zaizen Y, Okayama Y, Naito Y, Azuma K, Hoshino T. Feasibility re-evaluation of 75 mg/m(2) docetaxel in Japanese patients with previously treated non-small cell lung cancer. Jpn J Clin Oncol 2014; 44: 338-345.
  • Yokota-Nakatsuma A, Takeuchi H, Ohoka Y, Kato C, S-Y Song, Hoshino T, Yagita H, Ohteki T and Iwata M.Retinoic acid prevents mesenteric lymph node dendritic cells from inducing IL-13-producing inflammatory Th2 cells. Mucosal Immunol. 2014;7(4);786-801.
  • Takenaka S, Kawayama T, Imaoka H, Sakazakia Y, Oda H, Kaku Y, MatsuokaM, Okamoto M, Kato S, Yamada K, Hoshino T. The progression of comorbidity in IL-18 transgenic chronic obstructive pulmonary disease mice model. BBRC 2014; 445: 597-601.
  • Oda H, Kawayama T, Imaoka H, Sakazaki Y, Kaku Y, Okamoto M, Kitasato Y, Edakuni N, Takenaka S, Yoshida M, Iwanaga T, Kato S, O'Byrne PM, Hoshino T. Interleukin-18 expression, CD8+ T cells, and eosinophils in lungs of nonsmokers with fatal asthma. Ann Allergy Asthma Immunol 2014; 112: 23-28.
  • Azuma K, Ota K, Kawahara A, Hattori S, Iwama E, Harada T, Matsumoto K, Takayama K, Takamori S, Kage M , Hoshino T, Nakanishi Y, Okamoto I. Association of PD-L1 overexpression with activating EGFR mutations in surgically resected non–small cell lung cancer. Annals of Oncol .2014;10:1935-1940.
  • Azuma K, Kawahara A, Sonoda K, Nakashima K, Tashiro K, Watari K, Izumi H, Kage M, Kuwano M, Ono M, Hoshino T. FGFR1 activation is an escape mechanism in human lung cancer cells resistant to afatinib, a pan-EGFR family kinase inhibitor. Oncotarget .2014;5:5908-5919.
  • Ishii H, Azuma K, Yamada K, Kinoshita T, Imamura Y, Hoshino T. Predictive factors in patients with EGFR mutation-negative non-small cell lung cancer treated with erlotinib. Oncol Lett. 2014; 8: 2699-2704.
  • Suetomo M, Kawayama T, Kinoshita T, Takenaka S, Matsuoka M, Matsunaga K, Hoshino T. COPD assessment tests scores are associated with exacerbated chronic obstructive pulmonary disease in Japanese patients. Respir Investig. 2014;52(5):288-295.

原著:神経グループ

  • Yamashita KI, Taniwaki Y, Utsunomiya H, Taniwaki T. Cerebral blood flow reduction associated with orientation for time in amnestic mild cognitive impairment and Alzheimer disease patients. J. Neuroimaging. 2014 Mar 5.;10.1111/jon.12096.

原著:膠原病グループ

  • Kaieda S, Wang JX, Ameri S, Fishgal N, Dwyer D, Dellinger A, Kepley CL, Gurish MA, Nigrovic PA. The IL-33/ST2 axis promotes mast cell survival via BCL-XL. Proc Natl Acad Sci U.S.A. 2014;111(28):10281-6.
  • Migita K, Agematsu K, Yazaki M, Nonaka F, Nakamura A, Toma T, Kishida D,Uehara R,Nakamura Y, Jiuchi Y, Masumoto J, Furukawa H, Ida H, Terai C, Nakashima Y, Kawakami A, Nakamura T, Eguchi K, Yasunami M, Yachie A. Familial Mediterranean fever: genotype-phenotype correlations in Japanese patients. Medicine(Baltimore). 2014 May;93(3):158-64




2013

原著:呼吸器グループ

  • Imaoka H, Takenaka S, Kawayama T, Oda H, Kaku Y, Matsuoka M, Sakazaki Y, O'Byrne PM, Hoshino T. Increased serum levels of soluble IL-18 receptor complex in patients with allergic asthma. Allergol Int. 2013 Dec;62(4):513-5.
  • Yamada T, Azuma K, Muta E, Kim J, Sugawara S, Zhang GL, Matsueda S, Kasama-Kawaguchi Y, Yamashita Y, Yamashita T, Nishio K, Itoh K, Hoshino T, Sasada T. HLA-A0201-restricted T cell epitopes derived from the EGFR T790M mutation. PLos One 2013; 8: e78389.
  • Dua B, Smith S, Kinoshita T, et al.Myeloid dendritic cells type 2 in allergic asthma. Allergy. 2013;68(10):1322-6
  • Sawada M, Kawayama T, Imaoka H, Sakazaki Y, Oda H, Takenaka S, Kaku Y, Azuma K, Tajiri, M, Edakuni N, Okamoto M, Kato S, Hoshino T. IL-18 induces airway hyperresponsiveness and pulmonary inflammation via CD4+ T cell and IL-13. PLoS One, 2013; 8: e54623

原著:神経グループ

原著:膠原病グループ

  • Kobayashi M, Kaneko-Koike C, Abiru N, Uchida T, Akazawa S, Nakamura K, Kuriya G, Satoh T, Ida H, Kawasaki E, Yamasaki H, Nagayama Y, Sasaki H, Kawakami A.Genetic deletion of granzyme B does not confer resistance to the development of spontaneous diabetes in non-obese diabetic mice. Clin Exp Immunol.2013;173(3):411-8




2012.(January-December)

原著:呼吸器グループ

  • Morimatsu Y, Sakashita N, Komohara Y, Ohnishi K, Masuda H, Dahau D, Takeya M, Guibert C, Marthau R. Development and characterization of an animal model of severe pulmonary arterial hypertension. J Vasc Res 2012;49:33-42.
  • Uchida M, Shiraishi H, Ohta S, Arima K, Taniguchi K, Suzuki S, Okamoto M, Ahlfeld SK, Ohshima K, Kato S, Toda S, Sagara H, Aizawa H, Hoshino T, Conway SJ, Hayashi S, Izuhara K. Periostin, a matricellular protein, plays a role in the induction of chemokines in pulmonary fibrosis. Am J Respir Cell Mol Biol 2012;46:677-68.
  • Tsuda T, Suematsu R, Kamohara K, Kurose M, Arakawa I, Tomioka R, Kawayama T, Hoshino T, Aizawa H. Development of the japanese version of the copd assessment test. Respir Investig 2012;50:34-39.
  • Juliana FM, Nara H, Onoda T, Rahman M, Araki A, Jin L, Fujii H, Tanaka N, Hoshino T, Asao H. Apurinic/apyrimidinic endonuclease1/redox factor-1 (ape1/ref-1) is essential for il-21-induced signal transduction through erk1/2 pathway. Biochem Biophys Res Commun 2012;420:628-34.
  • Ito K, Kawayama T, Shoji Y, Fukushima N, Matsunaga K, Edakuni N, Uchimura N, Hoshino T. Depression but not sleep disorder is an independent factor affecting exacerbations and hospitalization in patients with chronic obstructive pulmonary disease. Respirology 2012;17:940-9.
  • Azuma K, Kawahara A, Hattori S, Taira T, Tsurutani J, Watari K, Shibata T, Murakami Y, Takamori S, Ono M, Izumi H, Kage M, Yanagawa T, Nakagawa K, Hoshino T, Kuwano M. Ndrg1/cap43/drg-1 may predict tumor angiogenesis and poor outcome in patients with lung cancer. J Thorac Oncol 2012;7:779-89.
  • Azuma K, Okamoto I, Kawahara A, Hattori S, Taira T, Nakashima K, Takamori S, Nakagawa K. Kage M, Kuwano M, Ono M. Association of the expression of mutant EGFR protein as determined with mutation-specific antibodies in non–small cell lung cancer with progression-free survival after gefitinib treatment. J Thorac Oncol 2012;7:122-7.
  • Tanizaki J, Okamoto I, Takezawa K, Sakai K, Azuma k, Kuwata K, Yamaguchi H, Hatashita E, Nishio K, Nakagawa K. Combined effect of ALK and MEK inhibitors in EML4-ALK-positive non-small-cell lung cancer cells. Br J Cancer 2012;106:763-7.
  • Tabara K, Kanda R, Sonoda K, Kubo T, Murakami Y, Kawahara A, Azuma K, Abe H, Kage M, Yoshinaga A, Tahira T, Hayashi K, Arao T, Nishio k, Rosell R, Kuwano M, Ono M. Loss of activating EGFR mutant gene contributes to acquired resistance to EGFR tyrosine kinase inhibitors in lung cancer cells. PLos One 2012;7:e41017.
  • Matsunaga K, Yanagisawa S, Hirano T, Ichikawa T, Koarai A, Akamatsu K, Sugiura H, Minakata Y, Matsunaga K, Kawayama T, Ichinose M.Associated demographics of persistent exhaled nitric oxide elevation in treated asthmatics. Clin Exp Allergy 2012;42:775-81.
  • Yamamoto N, Nokihara H, Yamada Y, Goto Y, Tanioka M, Shibata T, Yamada K, Asahina H, Kawata T, Shi X, Tamura T. A Phase I, dose-finding and pharmacokinetic study of olaparib (AZD2281) in Japanese patients with advanced solid tumors. Cancer Sci 2012;103:504-9.
  • Kinoshita T, Azuma K, Sasada T, Okamoto M, Hattori S, Imamura Y, Yamada K, Tajiri M, Yoshida T, Zaizen Y, Kawahara A, Fujimoto K, Hoshino T. Chemotherapy for non-small cell lung cancer complicated by interstitial pneumonia. Oncol Letters 2012 Sep;4(3):477-482.
  • Kawahara A, Taira T, Azuma K, Tominaga M, Hattori S, Kawahara M, Abe H, Yamaguchi T, Akiba J, Takamori S, Hayashi A, Kage M. A diagnostic algorithm using mutation-specific antibodies for rapid response EGFR-TKI treatment in patients with non-small cell lung cancer. Lung Cancer 2012 Oct;78(1):39-44.
  • Zaizen Y, Azuma K, Kurata S, Sadashima E, Hattori S, Sasada T, Imamura Y, Kaida H, Kawahara A, Kinoshita T, Ishibashi M, Hoshino T. Prognostic significance of total lesion glycolysis in patients with advanced non-small cell cancer receiving chemotherapy. Eur J Radiology 2012;81(12):4179-84.

原著:神経グループ

  • Miura S, Kida H, Nakajima J, Noda K, Nagasato K, Ayabe M, Aizawa H, Hauser M, Taniwaki T. Anhedonia in Japanese patients with Parkinson's disease: Analysis using the Snaith-Hamilton Pleasure Scale. Clin Neurol Neurosurg 2012;114:352-5.
  • Okubo H, Miyake Y, Sasaki S, Murakami K, Tanaka K, Fukushima W, Kiyohara C, Tsuboi Y, Yamada T, Oeda T, Shimada H, Kawamura N, Sakae N, Fukuyama H, Hirota Y, Nagai M; Fukuoka Kinki Parkinson’s Disease Study Group (Collaborators; Taniwaki T). Dietary patterns and risk of Parkinson's disease: a case-control study in Japan. Eur J Neurol 2012;19:681-8.
  • Miyake Y, Tanaka K, Fukushima W, Kiyohara C, Sasaki S, Tsuboi Y, Yamada T, Oeda T, Shimada H, Kawamura N, Sakae N, Fukuyama H, Hirota Y, Nagai M; Fukuoka Kinki Parkinson's Disease Study Group (Collaborators; Taniwaki T). SNCA polymorphisms, smoking, and sporadic Parkinson's disease in Japanese. Parkinsonism Relat Disord 2012;18:557-61.

原著:膠原病グループ

  • Migita K, Ida H, Moriuchi H, Agematsu K. Clinical relevance of MEFV genemutations in Japanese patients with unexplained fever. J Rheumatol 2012;39:875-7.
  • Kita J, Tamai M, Arima K, Nakashima Y, Suzuki T, Kawashiri SY, Iwamoto N,Okada A, Koga T, Yamasaki S, Nakamura H, Origuchi T, Ida H, Aoyagi K, Uetani M, Eguchi K, Kawakami A. Treatment discontinuation in patients with very early rheumatoid arthritis in sustained simplified disease activity index remission after synthetic disease-modifying anti-rheumatic drug administration. Mod Rheumatol 2012;22:346-52.
  • Kita J, Tamai M, Arima K, Nakashima Y, Suzuki T, Kawashiri SY, Okada A, Koga T, Yamasaki S, Nakamura H, Origuchi T, Aramaki T, Nakashima M, Fujikawa K, Tsukada T, Ida H, Aoyagi K, Uetani M, Eguchi K, Kawakami A. Delayed treatment with tumor necrosis factor inhibitors in incomplete responders to synthetic disease-modifying anti-rheumatic drugs shows an excellent effect in patients with very early rheumatoid arthritis with poor prognosis factors. Mod Rheumatol 2012;22:195-201, 2012.
  • Kaieda S, Wang J, Shnayder R, Fishgal N, Hei H, Lee RT, Stevens RL, Nigrovic PA. Interleukin-33 primes mast cells for activation by IgG immune complexes. PLoS One.(2012), in press.
  • Kaieda S, Kobayashi T, Moroki M, Honda S, Yuge K, Kawano H, Mitsuyama K, Sata M, Ida H, Hoshino T, Fukuda T. Successful treatment of rectal ulcers in a patient with systemic lupus erythematosus using corticosteroids and tacrolimus. Mod Rheumatol. (2012), in press.

All rights are reserved by Department of Medicine, Division of Respirology, Neurology, and Rheumatology, Kurume University School of Medicine, 2013.